The EPR effect is the property characterized by an increased accumulation of macromolecules, such as liposomes, drugs, and NPs in tumors versus in normal tissues. This is due to the fact that vasculature within a tumorous zone is leaky, with dysfunctional lymphatic system (Maeda et al., 2013; Perrault and Chan, 2010); therefore, it allows the easy access of these agents (Fig. 13.5A) (Fang et ...