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To standardize the pH meter, select two Buffer Solutions for Standardization whose difference in pH does not exceed 4 units and such that the expected pH of the material under test falls between them.
thermofisher.com DownloadThermo ScientificTM OrionTM pH meter kits are part of a high-quality pH test method designed to assist with compliance to USP When you take a medicine or supplement, you won’t get the therapeutic benefit unless the pill or capsule dissolves
This procedure describes the United States Pharmacopeia (USP) based protocol used to measure the pH of a sample solution independent of pH meter. This will apply to measurements of pH by Technical Operations in Good Manufacturing Practices/Good Laboratory Practices (GMP/GLP) applications in the Biopharmaceutical Development Program (BOP).
USP <791> outlines the requirements of the pH measuring system, including the pH meter and electrode. Those requirements have implications on the calibration and verification standards used.
Manufacturer’s instructions for pH meter calibration, pharmacopeial standards (e.g., USP), and internal quality control procedures.
For pH measurement, first, check the calibration of the pH meter as mentioned in 5.3.1 to 5.3.22. Rinse the electrode with Purified water and ensure that the pH meter is in measure mode (by pressing the Result key) to measure the pH of the test solution.
It explains the requirements for pH measurement systems, calibration procedures, and parameters. Typical calibration involves a 3-point calibration using buffers traceable to NIST and verifying the calibration in a buffer between the calibration points.
For compendial purposes, pH is defined as the value given by a suitable, properly calibrated, potentiometric sensor and measuring system. By definition, pH is equal to −log 10 [a H+] where a H+ is the activity of the hydrogen (H +) or hydronium ion (H 3 O +), and the hydrogen ion activity very closely approximates the hydrogen ion concentration.
Perform up to a 6-point pH calibration, and customize interchangeable modules for future measurement requirements. Backlit graphic screen displays the slope in the calibration log. Obtain offset value by exporting calibration log to a computer or printer, and perform up to a 5-point pH calibration. Waterproof, IP67-rated housing for protection.
For the temperature correction, when necessary, follow the manufacturer’s instructions. The apparatus is calibrated with the buffer solution of potassium hydrogen phthalate (primary standard) and 1 other buffer solution of different pH (preferably one shown in Table 2.2.3.-2).