Category ""
ADVERTISING
In the present study, we hypothesized that a certain mechanism other than simple diffusion is involved in the process of improved intestinal absorption of TBPM-PI and examined the mechanism.
absorption rate of TBPM-PI is higher than those of other prodrug-type -lactam antibiotics. In the present study, we hypothesized that a certain mechanism other than simple diffusion is invo.
Kato K, Shirasaka Y, Kuraoka E, Kikuchi A, Iguchi M, Suzuki H, Shibasaki S, Kurosawa T, Tamai I. 2010. Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport.
"Good transfer of tebipenem into middle ear effusion conduces to the favorable clinical outcomes of tebipenem pivoxil in pediatric patients with acute otitis media".
Through blood circulation, TBPM was distributed into the kidney at a high concentration and eliminated quickly. There was no other tissue than the kidney, in which TBPM was highly distributed and remained for a long time. In addition, low penetration to the central nervous system was confirmed.
In this study, we investigated the pharmacokinetics (PK) and tolerability of CFPN-PI following single oral administration in healthy Korean subjects. An open label, dose escalation, parallel group study was conducted in 18 healthy male volunteers.
This study evaluated the absorption, metabolism, and excretion of TBP-PI-HBr, following the administration of a single oral dose of [14 C]-TBP-PI-HBr to healthy males, and it also characterized the metabolites that were present in the plasma, urine, and feces.
Tebipenem pivoxil is licensed for use in Japan in children with ear, nose, and throat infections and respiratory infections. The HBr salt was designed to improve drug substance and drug product properties, including stability.
1. Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or p-glycoprotein. 2. Putative transport mechanism and intracellular fate of anti- 18 F-FACBC (Trans-1amino- 18 F-fluorocyclobutanecarboxylic acid) in human prostate cancer. 3.
Shirasaka Y, Suzuki K, Nakanishi T, Tamai I. Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.