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We unveil the distinct patterns of IGHV repertoire and discuss the correlation between IGHV and other genetic abnormalities in LPL/WM. IGHV4 usage was a predictive marker of shorter progression-free survival in patients with LPL/WM.
Die Diagnose der CLL basiert auf immunphänotypischen Kriterien und dem Nachweis monoklonaler B-Zellen im Blut. Die Erkrankung weist einen heterogenen Verlauf auf, und die Prognose wird durch genetische Marker wie den IGHV-Mutationsstatus und chromosomale Veränderungen beeinflusst.
IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution.
IGHV3-30 was associated with long heavy chain CDR3, indicating the speci c antigen selection in LPL/WM.
determine the cellular origin of primary mediastinal B-cell lymphoma based on the mutational patterns of IGHV and BCL6 genes and compare it to reactive tymic B-cells. 2. Compare the mutational landscape of the IGHV gene in lymph node and bone marrow involvement of follicular lymphoma.
Introduction: In several B-cell malignancies, such as chronic lymphocytic leukemia and mantle cell lymphoma, the somatic hypermutation (SHM) status of immunoglobulin heavy chain (IgH) variable region (V H) significantly correlates with clinical outcome.
Molecular analysis of Ig genes in malignant lymphoma over the last decade yielded findings consistent with normal B cell development and suggested normal counterparts of lymphoma cells, but it has also yielded differences and astonishing findings, hard to understand at the present time.
Next-generation sequencing (NGS)-based clonality assessment detects clonal rearrangements in B cell lymphoma specimen. B cell lymphoma specimen Blym1 was analyzed for IGH...
The narrowing of the immunoglobulin heavy chain variable region (IGHV) gene repertoire is a feature of chronic lymphocytic leukemia (CLL) and several other B-cell malignancies. In this study we examined the IGHV gene sequences of 1937 patients with the most common B-cell lymphomas. We present a detailed comparison
Chronic lymphocytic leukemia (CLL) cells may bear mutations in IGHV genes, the 2%-cutoff allowing to discriminate two subsets, unmutated (U)- or mutated (M)-CLL, with different clinical course.