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df_all = pd.read_csv('data.csv', error_bad_lines=False, chunksize=1000000) urls = pd.read_excel('url_june.xlsx') substr = urls.url.values.tolist() df_res = pd.DataFrame() for df in df_all: for i in substr: res = df[df['url'].str.contains(i)] df_res.append(res) And when I try to save df_res I get empty dataframe. df_all looks like
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