酒精诱导的镇静作用以及酒精与吗啡之间的协同相互作用:Toll 样受体和 MyD88 依赖性信号传导的关键机制作用 ...

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越来越多的证据表明吗啡诱导促炎性 Toll 样受体 (TLR) 2 和 TLR4 信号传导,酒精诱导 TLR4 信号传导;从而表明药物作用的共同位点和阿片类药物和酒精药物相互作用的潜在新型先天免疫依赖性假说。 因此,本研究旨在评估 TLR2、TLR4、MyD88(作为关键的 TLR 信号参与者)、NF-κB、白细胞介素-1β(IL-1β;作为下游促炎效应分子)和μ阿片受体(MOR;作为吗啡作用的经典位点)在急性酒精诱导的镇静 (4.5g/kg) 和酒精 (2.5g/kg) 与吗啡 (5mg/kg) 相互作用中的作用,通过评估扶正反射的丧失 (LORR) 作为镇静的衡量标准。


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