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Mast cell activation can be IgE-mediated or occur directly via antigens or stimulation of Toll-like receptors. 21 Mast cell degranulation has been observed in ILD in several studies. 22 Mast cell vesicles contain various profibrotic factors, such as IL-4 and transforming growth factor beta (TGF-β), and mast cells also produce metalloproteinases. 23 Our group has recently shown that ...
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