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Though Aβ biomarkers are still first to change, Jack and colleagues now separate out CSF Aβ and brain Aβ, with the former changing first. The group also combined 18F-fluorodeoxyglucose (FDG) PET and MRI into one curve where the previous diagram had not included FDG-PET. All markers are still represented as sigmoidal curves; however, the biomarkers that emerge later now sport a steeper final ...
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