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While A485 did not significantly affect IL-17 mRNA expression in control T H 17 cells, it lowered IL-17 mRNA expression in Lkb1 +/− T H 17 cells . Moreover, the expression of pro-inflammatory genes that constitute the pathogenic T H 17 signature (i.e., Il22 , Il23r , and Csf2 ) were all reduced in Lkb1 +/− T H 17 cells treated with A485 ( Fig. 6E and fig. S6A).
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