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Rare Blood Types and Their Significance. A unique combination of antigens makes a blood type rare. A rare blood type lacks the antigens most others (99%) are positive for. The rarest blood type, AB-, is present in 1% of Caucasians, 0.3% of African Americans, 0.1% of Asians, and 0.2% of Latino Americans. One of the rarest blood types is Bombay, first discovered in India.
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