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The tumor necrosis factor-α-induced-protein 3 (TNFAIP3, also known as A20, located on 6q23.3), and its interacting protein named as TNFAIP3 interacting protein 1 (TNIP1, located on 5q33.1) are both key regulators of NF-κB signaling pathway, modulating cell activation, cytokine signaling and apoptosis [90].
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