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Digestion takes place in the stomach and the small intestine. Pepsin is secreted in its zymogen form as pepsinogen by the chief cells of the stomach. Pepsinogen is activated to pepsin by gastric H+. The optimum pH for pepsin is between 1 and 3. Pepsin hydrolyzes proteins into peptones and proteoses. When the pH is >5, pepsin is denatured.
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