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Blood tests. If you have kidney disease, blood tests might show higher levels of the waste product creatinine or the protein cystatin C. Kidney biopsy. This procedure is the only way to confirm whether you have IgA nephropathy. A special needle is used to take out small pieces of kidney tissue. Then the tissue is checked under a microscope.
IgA nephropathy, or Berger’s disease, is a kidney disease in which IgA antibodies build up abnormally. Over time, it leads to kidney damage or kidney failure. Symptoms include blood in your pee, swelling and flank pain. Medications can slow the disease’s progress. But some people may need dialysis or a kidney transplant.
IgA nephropathy does not currently have a cure, but several medications are used to treat it, and lifestyle changes can be incorporated. The condition is a type of chronic kidney disease that causes damage to the glomeruli, which are the filters in the kidneys. 1 Treatment options for IgA nephropathy include medications and lifestyle changes.
About IgA Nephropathy IgA nephropathy (IgAN) is a type of kidney disease where antibodies build up in your kidneys and cause damage to your glomeruli (small filters inside your kidneys). Antibodies are a type of protein made by your immune system to protect against things like bacteria and viruses. The name is a combination of two parts:
Introduction Although IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis (GN) worldwide and has been first described more than 50 years ago, our understanding of the disease pathophysiology is still incomplete and treatment has remained largely empiric [1].
IgA nephropathy treatment and prognosis, including therapeutic options and factors affecting outcomes, are discussed in this comprehensive resource.
The treatment of primary IgA nephropathy (IgAN) is undergoing rapid change, based on new insights and novel approaches to care. Since its description by Hinglais and Berger, IgAN became established as the most common form of primary glomerular disease worldwide. 1-3 Though heterogeneous, it is increasingly recognized as a major cause of progressive kidney dysfunction and failure, which occurs ...
IgA nephropathy is a chronic kidney disease. It progresses over 10 to 20 years, and it can lead to end-stage renal disease. It is caused by deposits of the protein immunoglobulin A (IgA) inside the filters (glomeruli) in the kidney. These glomeruli normally filter waste and excess water from the ...
IgA nephropathy, or Berger disease, results from a buildup of the IgA antibody in the kidneys, leading to inflammation and potential kidney damage, but it can be managed through various treatments ...
The pathogenesis of immunoglobulin (Ig) A nephropathy is described through a “4-hit” model involving production of galactose-deficient IgA, production of autoantibodies to galactose-deficient IgA, and subsequent deposition of immune complexes in the kidney glomerulus. Diagnosis remains dependent on a kidney biopsy, often after hematuria or proteinuria is detected on urinalysis. The ...