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The term Shiga toxin-producing Escherichia coli (STEC) refers to an E. coli strain that acquired the capacity to produce a Shiga toxin, through transfer of gene by means of a Shiga-toxin (Stx) phage.
Affiliation 1 From the Departments of Pediatrics and Emergency Medicine, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada (S.B.F.); the Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, the Netherlands (N.C.A.J.K.); and ...
The bacteria which secrete Shiga toxin are Shigella dysenteriae, which causes intestinal infection with severe diarrhea most commonly in Asia, and certain strains of Escherichia coli (abbreviated as E. coli), which cause most of the ST-HUS in the Americas and Europe.
HUS is characterized by a triad of symptoms: microangiopathic haemolytic anaemia, thrombocytopenia and acute kidney injury. Most cases of HUS (90 %) occur as a single episode following infection with STEC [1].
Shiga toxin-producing Escherichia coli (STEC)-associated hemolytic uremic syndrome (STEC-HUS) is a clinical syndrome involving hemolytic anemia (with fragmented red blood cells), low levels of platelets in the blood (thrombocytopenia), and acute kidney injury (AKI).
Shiga toxin–producing Escherichia coli (STEC) are bacteria that carry the genes producing Shiga toxins. 1 These pathogens have the potential to cause diarrhea, which is often bloody, and...
The hemolytic-uremic syndrome (HUS) is a rare and serious disease. The condition predominates in young children and is frequently associated with an enteric infection due to serotype O157 Shiga toxin—producing Escherichia coli (STEC) [1]. Shiga toxins, namely STX1 and STX2, are thought to cause endothelial cell damage (primarily in the kidney ...
However, several studies have shown that complement plays an important role in the pathophysiology of Shiga toxin–producing Escherichia coli (STEC)–associated hemolytic–uremic syndrome...
Among Shiga-toxin-producing Escherichia coli (STEC), O157:H7 has the strongest association worldwide with HUS. Many different vehicles, in addition to the commonly suspected ground (minced) beef, can transmit this pathogen to people.
This study evaluates the long-term outcome of Shiga toxin-producing Escherichia coli-associated HUS (STEC-HUS) in pediatric patients, 10 years after the acute phase of disease to identify risk factors for long-term sequelae.