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To exploit the unique characteristics of aztreonam, recent investigations have explored the utility of aztreonam in combination with BL/BLIs. With this approach, a BL/BLI, such as ceftazidime-avibactam, inhibits ESBL and AmpC β-lactamases, whereas aztreonam evades MBL-mediated hydrolysis and exerts its bactericidal effects.
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