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Chronic Spontaneous Urticaria is defined as urticaria, histaminergic angioedema, or both – for a period of six weeks or longer. Angioedema causes painless swelling usually around the eyes, lips, face, extremities or genitals. Urticaria may occur alone (50% of cases), with angioedema (40% of cases), or histaminergic angioedema
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