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Sferocitoza upućuje na hipersplenizam ili hereditarnu sferocitozu. Rezultati ispitivanja jetrenih funkcija difuzno odstupaju od normale kod kongestivne splenomegalije s cirozom; izolirano povišenje serumske alkalne fosfataze ukazuje na jetrenu infiltraciju, kao kod mijeloproliferativnih i limfoproliferativnih bolesti, milijarne TBC , i ...
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