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The expression of PD-L1 in cancer cells, including OC, is upregulated by type II interferon, IFNγ [11, 12]. IFNγ is produced mainly by activated T cells, but also by cancer cells in response to radiation therapy or immune checkpoint blockade used in cancer treatment [12]. IFNγ signals primarily via the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway to ...
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