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The tumor necrosis factor alpha-induced protein (TNFAIP3), also known as A20, is a key regulator of the inflammatory responses. TNFAIP3 negatively regulates the TNF-induced NF-κB proinflammatory signalling pathway, participates in B cell survival and controls TNF-mediated apoptosis [44]. The TNFAIP3 locus is
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