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La sindrome RS3PE (Remitting Seronegative Symmetrical Synovitis with Pitting Edema) o Poliartrite subacuta edematosa benigna dell’anziano è una sindrome clinica ad insorgenza acuta caratterizzata da sinovite simmetrica e bilaterale prevalentemente a carico dei polsi, mani e talora piedi, con edema improntabile e ad evoluzione benigna.
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