Oxidative stress in health and disease: The therapeutic ...

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The term “oxidative stress” began to be used frequently in the 1970s, but its conceptual origins can be traced back to the 1950s to researchers pondering the toxic effects of ionizing radiation, free radicals, and the similar toxic effects of molecular oxygen (Gerschman et al., 1954), and the potential contribution of such processes to the phenomenon of aging (Harman, 1956).


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