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Overall, this study is an important advance in molecular biomarkers for Alzheimer’s disease. I am impressed by the robustness of the YWHAG:NPTX2 ratio in the CSF and how quantitative it is as a biomarker of cognitive impairment, independent of tau/Aβ measures. The YWHAG:NPTX2 ratio also performs remarkably well as a predictor of progression ...
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