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Amitriptyline has a half-life ranging from 10 to 28 hours. The half-life of a drug is the time it takes for the blood concentration of a drug to reduce by one-half. It takes about 5 half-lives for a drug to be fully eliminated from your body. So, after about 50 to 140 hours (about 2 to 6 days), most of amitriptyline is gone from your body.
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