脑声常谈:如何建立动物慢性社会挫败应激模型(CSDS ...

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建立动物慢性社会挫败应激模型(chronic social defeat stress model, CSDS)通常是为了研究抑郁症、焦虑症等心理疾病的发病机制。 这种模型通常使用小鼠或大鼠作为实验动物。 选择实验动物:选择适当的实验动物(如小鼠或大鼠),并将其分为实验组和对照组。 实验组的动物将经历慢性社会挫败应激,而对照组的动物将不会受到应激刺激。 选择侵略者:从实验动物群体中选择具有侵略性的个体作为侵略者。 为了确保侵略者的侵略性,可以使用屏障分隔的笼子让侵略者和实验组动物短暂适应彼此的气味。 慢性社会挫败应激:每天将实验组的动物暴露在侵略者面前,使其经历慢性社会挫败应激。 通常,每次应激时间为10-30分钟,持续10-14天。


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